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UniProt functional annotation for P08176 | ||
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| UniProt code: P08176. |
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| Organism: | |
Dermatophagoides pteronyssinus (European house dust mite). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea; Pyroglyphidae; Dermatophagoidinae; Dermatophagoides. |
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| Function: | |
Thiol protease, with a preference for substrates with a large hydrophobic side chain in the P2 position, or with basic residues. |
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| Catalytic activity: | |
Reaction=Broad endopeptidase specificity.; EC=3.4.22.65; |
| Subcellular location: | |
Secreted. |
| Ptm: | |
N-glycosylated. N-glycanase treatment does not completely remove carbohydrates, suggesting that the protein contains additional glycosylation sites. {ECO:0000269|PubMed:16148130}. |
| Allergen: | |
Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE in 80% of patients with house dust allergy. |
| Similarity: | |
Belongs to the peptidase C1 family. {ECO:0000255|PROSITE- ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}. |
| Sequence caution: | |
Sequence=AAA28296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.