UniProt functional annotation for P70211



	UniProt functional annotation for P70211

UniProt code: P70211.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Subunit: Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Interacts with MAPK1 (By similarity). Interacts with NTN1 (By similarity). Interacts with DSCAM (PubMed:18585357). Interacts with PTK2/FAK1 (PubMed:15494734). Interacts with MYO10 (PubMed:21321230). Interacts with CBLN4; this interaction can be competed by NTN1 (PubMed:22220752, PubMed:29782851). Interacts with SIAH1 and SIAH2 (By similarity). {ECO:0000250|UniProtKB:P43146, ECO:0000250|UniProtKB:Q63155, ECO:0000269|PubMed:15494734, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:21321230, ECO:0000269|PubMed:22220752, ECO:0000269|PubMed:29782851}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: In the embryo, expressed at high levels in the developing brain and neural tube. In the embryo, expressed in developing neurons of the telencephalic cortical plate and in developing brainstem nuclei (PubMed:28250456). In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo. {ECO:0000269|PubMed:28250456}.

Developmental stage: Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Ptm: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:P43146}.

Miscellaneous: [Isoform B]: Produced by alternative initiation at Met- 85 of isoform A. {ECO:0000305}.

Similarity: Belongs to the immunoglobulin superfamily. DCC family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.


Subunit:		Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Interacts with MAPK1 (By similarity). Interacts with NTN1 (By similarity). Interacts with DSCAM (PubMed:18585357). Interacts with PTK2/FAK1 (PubMed:15494734). Interacts with MYO10 (PubMed:21321230). Interacts with CBLN4; this interaction can be competed by NTN1 (PubMed:22220752, PubMed:29782851). Interacts with SIAH1 and SIAH2 (By similarity). {ECO:0000250\|UniProtKB:P43146, ECO:0000250\|UniProtKB:Q63155, ECO:0000269\|PubMed:15494734, ECO:0000269\|PubMed:18585357, ECO:0000269\|PubMed:21321230, ECO:0000269\|PubMed:22220752, ECO:0000269\|PubMed:29782851}.
Subcellular location:		Membrane; Single-pass type I membrane protein.
Tissue specificity:		In the embryo, expressed at high levels in the developing brain and neural tube. In the embryo, expressed in developing neurons of the telencephalic cortical plate and in developing brainstem nuclei (PubMed:28250456). In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo. {ECO:0000269\|PubMed:28250456}.
Developmental stage:		Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.
Ptm:		Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250\|UniProtKB:P43146}.
Miscellaneous:		[Isoform B]: Produced by alternative initiation at Met- 85 of isoform A. {ECO:0000305}.
Similarity:		Belongs to the immunoglobulin superfamily. DCC family. {ECO:0000305}.