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PDBsum entry 4pln
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Protein binding
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PDB id
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4pln
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References listed in PDB file
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Key reference
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Title
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Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
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Authors
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K.Xu,
Z.Wu,
N.Renier,
A.Antipenko,
D.Tzvetkova-Robev,
Y.Xu,
M.Minchenko,
V.Nardi-Dei,
K.R.Rajashankar,
J.Himanen,
M.Tessier-Lavigne,
D.B.Nikolov.
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Ref.
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Science, 2014,
344,
1275-1279.
[DOI no: ]
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PubMed id
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Abstract
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Netrins are secreted proteins that regulate axon guidance and neuronal
migration. Deleted in colorectal cancer (DCC) is a well-established netrin-1
receptor mediating attractive responses. We provide evidence that its close
relative neogenin is also a functional netrin-1 receptor that acts with DCC to
mediate guidance in vivo. We determined the structures of a functional netrin-1
region, alone and in complexes with neogenin or DCC. Netrin-1 has a rigid
elongated structure containing two receptor-binding sites at opposite ends
through which it brings together receptor molecules. The ligand/receptor
complexes reveal two distinct architectures: a 2:2 heterotetramer and a
continuous ligand/receptor assembly. The differences result from different
lengths of the linker connecting receptor domains fibronectin type III domain 4
(FN4) and FN5, which differs among DCC and neogenin splice variants, providing a
basis for diverse signaling outcomes.
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