PDBsum entry 4p2y

Signaling protein

PDB id: 4p2y

Contents

Protein chains

301 a.a.

88 a.a.

Ligands

ACT ×7

Metals

_ZN ×6

_CL ×6

_CA ×2

Waters ×186

PDB id:

4p2y

Name:

Signaling protein

Title:

Crystal structure of the human rage ectodomain (fragment vc1c2) in complex with mouse s100a6

Structure:

Advanced glycosylation end product-specific receptor. Chain: a. Fragment: v, c1 and c2 domains (vc1c2 module), full-length ectodomain, unp residues 23-323. Synonym: receptor for advanced glycosylation end products. Engineered: yes. Protein s100-a6. Chain: b. Synonym: 5b10, calcyclin, prolactin receptor-associated protein, s100

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ager, rage. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Resolution:

2.30Å R-factor: 0.188 R-free: 0.207

Authors:

L.Yatime,G.R.Andersen

Key ref:

L.Yatime et al. (2016). The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins. Structure, 24, 2043-2052. PubMed id: 27818100 DOI: 10.1016/j.str.2016.09.011

Date:

05-Mar-14 Release date: 11-Mar-15

Protein chain

Q15109  (RAGE_HUMAN) -  Advanced glycosylation end product-specific receptor from Homo sapiens

Seq: 404 a.a.

Struc: 301 a.a.*

Protein chain

P14069  (S10A6_MOUSE) -  Protein S100-A6 from Mus musculus

Seq: 89 a.a.

Struc: 88 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1016/j.str.2016.09.011

Structure 24:2043-2052 (2016)

PubMed id: 27818100

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

L.Yatime, C.Betzer, R.K.Jensen, S.Mortensen, P.H.Jensen, G.R.Andersen.

ABSTRACT

No abstract given.