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PDBsum entry 4orz
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Transferase/apoptosis/immune system
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PDB id
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4orz
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Contents |
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56 a.a.
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117 a.a.
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114 a.a.
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PDB id:
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| Name: |
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Transferase/apoptosis/immune system
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Title:
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HIV-1 nef protein in complex with single domain antibody sdab19 and an engineered hck sh3 domain
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Structure:
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Tyrosine-protein kinase hck. Chain: a. Fragment: sh3 domain, unp residues 77-138. Synonym: hematopoietic cell kinase, hemopoietic cell kinase, p59- hck/p60-hck, p59hck, p61hck. Engineered: yes. Mutation: yes. Protein nef. Chain: b.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli. Expression_system_taxid: 469008. HIV-1 m:b_arv2/sf2. HIV-1. Organism_taxid: 11685.
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Resolution:
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2.00Å
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R-factor:
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0.204
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R-free:
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0.236
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Authors:
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M.Geyer,S.Lulf
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Key ref:
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S.Lülf
et al.
(2014).
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology,
11,
24.
PubMed id:
DOI:
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Date:
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12-Feb-14
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Release date:
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26-Mar-14
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PROCHECK
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Headers
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References
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P08631
(HCK_HUMAN) -
Tyrosine-protein kinase HCK from Homo sapiens
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Seq:
Struc:
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526 a.a.
56 a.a.*
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Enzyme class 2:
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Chain A:
E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Enzyme class 3:
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Chain B:
E.C.?
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Retrovirology
11:24
(2014)
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PubMed id:
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Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
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S.Lülf,
J.Matz,
M.C.Rouyez,
A.Järviluoma,
K.Saksela,
S.Benichou,
M.Geyer.
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ABSTRACT
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Links
