PDBsum entry 4omm

Transferase

PDB id: 4omm

Contents

Protein chain

57 a.a.

Ligands

PGE

PEG ×2

GOL

SO4

Waters ×32

PDB id:

4omm

Name:

Transferase

Title:

Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant n113s

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a. Fragment: sh3 domain. Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.90Å R-factor: 0.176 R-free: 0.213

Authors:

A.Camara-Artigas,J.Bacarizo

Key ref:

A.Camara-Artigas et al. The role of gutamine 128 of the sh3 domain of the c-S tyrosine kinase in 3d domain swapping and amyloid for. To be published, .

Date:

27-Jan-14 Release date: 28-Jan-15

Protein chain

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 57 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site