PDBsum entry 4oli

Transferase

PDB id: 4oli

Contents

Protein chain

539 a.a.

Ligands

2TT ×2

Waters ×8

PDB id:

4oli

Name:

Transferase

Title:

The pseudokinase/kinase protein from jak-family member tyk2

Structure:

Non-receptor tyrosine-protein kinase tyk2. Chain: a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.80Å R-factor: 0.205 R-free: 0.257

Authors:

C.Eigenbrot,M.Ultsch,H.Wallweber

Key ref:

P.J.Lupardus et al. (2014). Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proc Natl Acad Sci U S A, 111, 8025-8030. PubMed id: 24843152 DOI: 10.1073/pnas.1401180111

Date:

23-Jan-14 Release date: 28-May-14

Protein chain

P29597  (TYK2_HUMAN) -  Non-receptor tyrosine-protein kinase TYK2 from Homo sapiens

Seq: 1187 a.a.

Struc: 539 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1073/pnas.1401180111

Proc Natl Acad Sci U S A 111:8025-8030 (2014)

PubMed id: 24843152

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

P.J.Lupardus, M.Ultsch, H.Wallweber, P.Bir Kohli, A.R.Johnson, C.Eigenbrot.

ABSTRACT

No abstract given.