PDBsum entry 4okh

Hydrolase

PDB id: 4okh

Contents

Protein chains

171 a.a.

147 a.a.

Ligands

PEU ×2

Metals

_CA ×11

Waters ×46

PDB id:

4okh

Name:

Hydrolase

Title:

Crystal structure of calpain-3 penta-ef-hand domain

Structure:

Calpain-3. Chain: a, b, c. Fragment: penta ef-hand domain. Synonym: calcium-activated neutral proteinase 3, canp 3, calpain l3, calpain p94, muscle-specific calcium-activated neutral protease 3, new calpain 1, ncl-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: can3, canp3, canpl3, capn3, ncl1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.45Å R-factor: 0.202 R-free: 0.269

Authors:

S.Karunan Partha,R.Ravulapalli,R.L.Campbell,J.S.Allingham,P.L.Davies

Key ref:

S.K.Partha et al. (2014). Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-hand. Febs J, 281, 3138-3149. PubMed id: 24846670 DOI: 10.1111/febs.12849

Date:

22-Jan-14 Release date: 28-May-14

Protein chains

P20807  (CAN3_HUMAN) -  Calpain-3 from Homo sapiens

Seq: 821 a.a.

Struc: 171 a.a.

Protein chain

P20807  (CAN3_HUMAN) -  Calpain-3 from Homo sapiens

Seq: 821 a.a.

Struc: 147 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C: E.C.3.4.22.54 - calpain-3.
• Cofactor: Ca(2+)

DOI no: 10.1111/febs.12849

Febs J 281:3138-3149 (2014)

PubMed id: 24846670

Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-hand.

S.K.Partha, R.Ravulapalli, J.S.Allingham, R.L.Campbell, P.L.Davies.

ABSTRACT

No abstract given.