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PDBsum entry 4oia
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Cell adhesion
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PDB id
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4oia
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References listed in PDB file
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Key reference
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Title
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Crystal structures of an icam-5 ectodomain fragment show electrostatic-Based homophilic adhesions.
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Authors
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R.Recacha,
D.Jiménez,
L.Tian,
R.Barredo,
C.G.Gahmberg,
J.M.Casasnovas.
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Ref.
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Acta Crystallogr D Biol Crystallogr, 2014,
70,
1934-1943.
[DOI no: ]
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PubMed id
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Abstract
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Intercellular cell adhesion molecule-5 (ICAM-5) is a member of the ICAM
subfamily that is exclusively expressed in the telencephalon region of the
brain. The crystal structure of the four most N-terminal glycosylated domains
(D1-D4) of ICAM-5 was determined in three different space groups and the D1-D5
fragment was modelled. The structures showed a curved molecule with two
pronounced interdomain bends between D2 and D3 and between D3 and D4, as well as
some interdomain flexibility. In contrast to ICAM-1, ICAM-5 has patches of
positive and negative electrostatic charge at D1-D2 and at D3-D5, respectively.
ICAM-5 can mediate homotypic interactions. In the crystals, several charge-based
intermolecular interactions between the N-terminal and C-terminal moieties of
the ICAM-5 molecules were observed, which defined an interacting surface in the
D1-D4 fragment. One of the crystal lattices has a molecular assembly that could
represent the homophilic ICAM-5 cell adhesion complex in neurons.
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