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PDBsum entry 4oi9
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Cell adhesion
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PDB id
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4oi9
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PDB id:
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| Name: |
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Cell adhesion
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Title:
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Crystal structure of icam-5 d1-d4 ectodomain fragment, space group p21
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Structure:
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Intercellular adhesion molecule 5. Chain: a. Fragment: d1-d4. Synonym: icam-5, telencephalin. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: icam5, tlcn, tln. Expressed in: homo sapiens. Expression_system_taxid: 9606
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Resolution:
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2.50Å
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R-factor:
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0.251
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R-free:
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0.263
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Authors:
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R.Recacha,D.Jimenez,L.Tian,R.Barredo,C.Ghamberg,J.M.Casasnovas
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Key ref:
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R.Recacha
et al.
(2014).
Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
Acta Crystallogr D Biol Crystallogr,
70,
1934-1943.
PubMed id:
DOI:
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Date:
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19-Jan-14
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Release date:
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16-Jul-14
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PROCHECK
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Headers
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References
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Q9UMF0
(ICAM5_HUMAN) -
Intercellular adhesion molecule 5 from Homo sapiens
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Seq:
Struc:
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924 a.a.
378 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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DOI no:
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Acta Crystallogr D Biol Crystallogr
70:1934-1943
(2014)
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PubMed id:
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Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
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R.Recacha,
D.Jiménez,
L.Tian,
R.Barredo,
C.G.Gahmberg,
J.M.Casasnovas.
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ABSTRACT
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Intercellular cell adhesion molecule-5 (ICAM-5) is a member of the ICAM
subfamily that is exclusively expressed in the telencephalon region of the
brain. The crystal structure of the four most N-terminal glycosylated domains
(D1-D4) of ICAM-5 was determined in three different space groups and the D1-D5
fragment was modelled. The structures showed a curved molecule with two
pronounced interdomain bends between D2 and D3 and between D3 and D4, as well as
some interdomain flexibility. In contrast to ICAM-1, ICAM-5 has patches of
positive and negative electrostatic charge at D1-D2 and at D3-D5, respectively.
ICAM-5 can mediate homotypic interactions. In the crystals, several charge-based
intermolecular interactions between the N-terminal and C-terminal moieties of
the ICAM-5 molecules were observed, which defined an interacting surface in the
D1-D4 fragment. One of the crystal lattices has a molecular assembly that could
represent the homophilic ICAM-5 cell adhesion complex in neurons.
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