UniProt functional annotation for Q9U3P2



	UniProt functional annotation for Q9U3P2

UniProt code: Q9U3P2.

Organism: Caenorhabditis elegans.

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.

Function: Cell adhesion protein (PubMed:15035988). Determines synapse formation (PubMed:15035988, PubMed:21858180, PubMed:24485456). Required for correct localization of syg-1 at synaptic sites (PubMed:15035988). {ECO:0000269|PubMed:15035988, ECO:0000269|PubMed:21858180, ECO:0000269|PubMed:24485456}.

Subunit: Interacts with syg-1. {ECO:0000269|PubMed:21858180, ECO:0000269|PubMed:24485456}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, synapse {ECO:0000269|PubMed:24485456}.

Tissue specificity: Expressed in vulval epithelial cells. {ECO:0000269|PubMed:18675916, ECO:0000269|PubMed:21858180}.

Developmental stage: Expressed in head neurons and body wall muscles during embryogenesis (PubMed:15035988). Expressed in head and body wall muscles and in punctate structures near the ventral nerve cord during larval stages L1 and L2 (PubMed:15035988). Expressed in primary vulval epithelial cells from larval stage L3, with expression increasing upon entry into L4 and diminished within six hours of adulthood (PubMed:15035988, PubMed:18675916). {ECO:0000269|PubMed:15035988, ECO:0000269|PubMed:18675916}.

Domain: The first five extracellular Ig-like domains are required for correct localization of syg-1. {ECO:0000269|PubMed:18675916}.

Domain: The cytoplasmic domain is necessary for syg-2 subcellular localization. {ECO:0000269|PubMed:18675916}.

Disruption phenotype: Animals are viable, fertile, egg-laying proficient and coordinated. Abnormal synaptic vesicle clustering in the HSNL motor neuron from larval stage L3 through to adulthood. Reduced accumulation of synaptic vesicle proteins snb-1 and cat-1 in HSNL motor neuron. Defective synapse specificity due to altered distribution of synapses. syg-1 is mis-localized and diffusely distributed on the axon of the HSNL neuron. {ECO:0000269|PubMed:15035988}.

Annotations taken from UniProtKB at the EBI.


Organism:		Caenorhabditis elegans.
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.



Function:		Cell adhesion protein (PubMed:15035988). Determines synapse formation (PubMed:15035988, PubMed:21858180, PubMed:24485456). Required for correct localization of syg-1 at synaptic sites (PubMed:15035988). {ECO:0000269\|PubMed:15035988, ECO:0000269\|PubMed:21858180, ECO:0000269\|PubMed:24485456}.


Subunit:		Interacts with syg-1. {ECO:0000269\|PubMed:21858180, ECO:0000269\|PubMed:24485456}.
Subcellular location:		Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, synapse {ECO:0000269\|PubMed:24485456}.
Tissue specificity:		Expressed in vulval epithelial cells. {ECO:0000269\|PubMed:18675916, ECO:0000269\|PubMed:21858180}.
Developmental stage:		Expressed in head neurons and body wall muscles during embryogenesis (PubMed:15035988). Expressed in head and body wall muscles and in punctate structures near the ventral nerve cord during larval stages L1 and L2 (PubMed:15035988). Expressed in primary vulval epithelial cells from larval stage L3, with expression increasing upon entry into L4 and diminished within six hours of adulthood (PubMed:15035988, PubMed:18675916). {ECO:0000269\|PubMed:15035988, ECO:0000269\|PubMed:18675916}.
Domain:		The first five extracellular Ig-like domains are required for correct localization of syg-1. {ECO:0000269\|PubMed:18675916}.
Domain:		The cytoplasmic domain is necessary for syg-2 subcellular localization. {ECO:0000269\|PubMed:18675916}.
Disruption phenotype:		Animals are viable, fertile, egg-laying proficient and coordinated. Abnormal synaptic vesicle clustering in the HSNL motor neuron from larval stage L3 through to adulthood. Reduced accumulation of synaptic vesicle proteins snb-1 and cat-1 in HSNL motor neuron. Defective synapse specificity due to altered distribution of synapses. syg-1 is mis-localized and diffusely distributed on the axon of the HSNL neuron. {ECO:0000269\|PubMed:15035988}.