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UniProt functional annotation for Q9Y624 | ||
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| UniProt code: Q9Y624. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T- cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}. |
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| Subunit: | |
Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913). Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain) (PubMed:15528364). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:15528364}. |
| Subunit: | |
(Microbial infection) Interacts with Mammalian reovirus sigma- 1 capsid protein. {ECO:0000269|PubMed:11239401}. |
| Subunit: | |
(Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein. {ECO:0000269|PubMed:25481868}. |
| Subcellular location: | |
Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269|PubMed:11171323}. |
| Tissue specificity: | |
Expressed in endothelium, epithelium and leukocytes (at protein level). {ECO:0000269|PubMed:11812992}. |
| Domain: | |
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2. {ECO:0000269|PubMed:11812992}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7646439}. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.