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UniProt functional annotation for P04506 | ||
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| UniProt code: P04506. |
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| Organism: | |
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes; Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus. |
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| Function: | |
Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). {ECO:0000250}. |
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| Subunit: | |
Homotrimer. Interacts (via the head region) with human F11R (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Virion {ECO:0000250}. Note=Found in the outer capsid (36 copies). {ECO:0000250}. |
| Ptm: | |
Undergoes dramatic conformational rearrangements during viral disassembly in the endocytic pathway. {ECO:0000250}. |
| Similarity: | |
Belongs to the orthoreovirus sigma-1 protein family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA47276.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA66877.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.