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PDBsum entry 4nxq
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Signaling protein/peptide
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PDB id
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4nxq
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PDB id:
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| Name: |
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Signaling protein/peptide
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Title:
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Crystal structure of t-cell lymphoma invasion and metastasis-1 pdz domain quadruple mutant (qm) in complex with caspr4 peptide
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Structure:
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T-lymphoma invasion and metastasis-inducing protein 1. Chain: a, b, c. Fragment: pdz domain. Synonym: tiam-1. Engineered: yes. Mutation: yes. Contactin-associated protein-like 4 peptide. Chain: d, e, f. Fragment: unp residues 1301-1308.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: tiam1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.10Å
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R-factor:
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0.188
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R-free:
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0.236
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Authors:
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X.Liu,D.C.Speckhard,T.R.Shepherd,S.R.Hengel,E.J.Fuentes
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Key ref:
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X.Liu
et al.
(2016).
Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
Structure,
24,
2053-2066.
PubMed id:
DOI:
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Date:
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09-Dec-13
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Release date:
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13-May-15
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PROCHECK
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Headers
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References
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Q13009
(TIAM1_HUMAN) -
Rho guanine nucleotide exchange factor TIAM1 from Homo sapiens
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Seq:
Struc:
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1591 a.a.
91 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 7 residue positions (black
crosses)
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DOI no:
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Structure
24:2053-2066
(2016)
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PubMed id:
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Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
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X.Liu,
D.C.Speckhard,
T.R.Shepherd,
Y.J.Sun,
S.R.Hengel,
L.Yu,
C.A.Fowler,
L.Gakhar,
E.J.Fuentes.
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ABSTRACT
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Links
