PDBsum entry 4nxp

Signaling protein

PDB id: 4nxp

Contents

Protein chain

86 a.a.

Waters ×47

PDB id:

4nxp

Name:

Signaling protein

Title:

Crystal structure of free t-cell lymphoma invasion and metastasis-1 pdz domain quadruple mutant (qm)

Structure:

T-lymphoma invasion and metastasis-inducing protein 1. Chain: a. Fragment: pdz domain. Synonym: tiam-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: tiam1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.30Å R-factor: 0.219 R-free: 0.258

Authors:

X.Liu,D.C.Speckhard,T.R.Shepherd,S.R.Hengel,E.J.Fuentes

Key ref:

X.Liu et al. (2016). Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure, 24, 2053-2066. PubMed id: 27998539 DOI: 10.1016/j.str.2016.08.019

Date:

09-Dec-13 Release date: 13-May-15

Protein chain

Q13009  (TIAM1_HUMAN) -  Rho guanine nucleotide exchange factor TIAM1 from Homo sapiens

Seq: 1591 a.a.

Struc: 86 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

DOI no: 10.1016/j.str.2016.08.019

Structure 24:2053-2066 (2016)

PubMed id: 27998539

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.

X.Liu, D.C.Speckhard, T.R.Shepherd, Y.J.Sun, S.R.Hengel, L.Yu, C.A.Fowler, L.Gakhar, E.J.Fuentes.

ABSTRACT

No abstract given.