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PDBsum entry 4nr8
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Transcription/inhibitor
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PDB id
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4nr8
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PDB id:
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| Name: |
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Transcription/inhibitor
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Title:
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Crystal structure of the first bromodomain of human brd4 in complex with an isoxazolyl-benzimidazole ligand
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Structure:
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Bromodomain-containing protein 4. Chain: a. Fragment: unp residues 44-168. Synonym: protein hunk1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.64Å
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R-factor:
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0.215
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R-free:
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0.246
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Authors:
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P.Filippakopoulos,S.Picaud,I.Felletar,D.Hay,O.Fedorov,S.Martin,F.Von Delft,P.Brennan,C.H.Arrowsmith,A.M.Edwards,C.Bountra,S.Knapp, Structural Genomics Consortium (Sgc)
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Key ref:
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P.Filippakopoulos
et al.
Crystal structure of the first bromodomain of human b complex with an isoxazolyl-Benzimidazole ligand.
To be published,
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Date:
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26-Nov-13
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Release date:
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25-Dec-13
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PROCHECK
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Headers
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References
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O60885
(BRD4_HUMAN) -
Bromodomain-containing protein 4 from Homo sapiens
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Seq:
Struc:
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1362 a.a.
125 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Links
