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PDBsum entry 4nr6
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Transcription/inhibitor
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PDB id
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4nr6
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PDB id:
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| Name: |
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Transcription/inhibitor
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Title:
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Crystal structure of the bromodomain of human crebbp in complex with an oxazepin ligand
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Structure:
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Creb-binding protein. Chain: a. Fragment: unp residues 1081-1197. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cbp, crebbp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.66Å
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R-factor:
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0.181
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R-free:
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0.231
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Authors:
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P.Filippakopoulos,S.Picaud,I.Felletar,D.Hay,O.Fedorov,S.Martin, A.Chaikuad,F.Von Delft,P.Brennan,C.H.Arrowsmith,A.M.Edwards, C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
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Key ref:
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P.Filippakopoulos
et al.
Crystal structure of the bromodomain of human crebbp complex with an oxazepin ligand.
To be published,
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Date:
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26-Nov-13
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Release date:
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18-Dec-13
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PROCHECK
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Headers
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References
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Q92793
(CBP_HUMAN) -
CREB-binding protein from Homo sapiens
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Seq:
Struc:
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2442 a.a.
116 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 1:
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E.C.2.3.1.-
- ?????
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Enzyme class 2:
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E.C.2.3.1.48
- histone acetyltransferase.
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Reaction:
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L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+
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L-lysyl-[protein]
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+
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acetyl-CoA
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=
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N(6)-acetyl-L-lysyl-[protein]
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+
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CoA
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
