PDBsum entry 4nr4

Transcription/inhibitor

PDB id: 4nr4

Contents

Protein chains

113 a.a.

Ligands

2LK ×3

EDO ×2

Metals

_MG

Waters ×286

PDB id:

4nr4

Name:

Transcription/inhibitor

Title:

Crystal structure of the bromodomain of human crebbp in complex with an isoxazolyl-benzimidazole ligand

Structure:

Creb-binding protein. Chain: a, b. Fragment: unp residues 1081-1197. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cbp, crebbp. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.69Å R-factor: 0.156 R-free: 0.192

Authors:

P.Filippakopoulos,S.Picaud,I.Felletar,D.Hay,O.Fedorov,S.Martin,F.Von Delft,P.Brennan,C.H.Arrowsmith,A.M.Edwards,C.Bountra,S.Knapp, Structural Genomics Consortium (Sgc)

Key ref:

P.Filippakopoulos et al. Crystal structure of the bromodomain of human crebbp complex with an isoxazolyl-Benzimidazole ligand. To be published, .

Date:

26-Nov-13 Release date: 18-Dec-13

Protein chains

Q92793  (CBP_HUMAN) -  CREB-binding protein from Homo sapiens

Seq: 2442 a.a.

Struc: 113 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.3.1.- - ?????
• Enzyme class 2: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site