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PDBsum entry 4npv
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Hydrolase/hydrolase inhibitor
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PDB id
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4npv
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure of human pde1b bound to inhibitor 7a (6,7,8- trimethoxy-n-(pentan-3-yl)quinazolin-4-amine)
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Structure:
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Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1b. Chain: a. Fragment: unp residues 142-507. Synonym: cam-pde 1b, 63 kda cam-pde. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pde1b, pde1b1, pdes1b. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.40Å
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R-factor:
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0.207
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R-free:
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0.236
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Authors:
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J.Pandit,A.Evdomikov,M.Mansour,S.Simons
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Key ref:
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J.M.Humphrey
et al.
Small-Molecule phosphodiesterase probes: discovery of and selective cns-Penetrable quinazoline inhibitors o.
Medchemcomm,
.
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Date:
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22-Nov-13
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Release date:
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16-Jul-14
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PROCHECK
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Headers
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References
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Q01064
(PDE1B_HUMAN) -
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B from Homo sapiens
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Seq:
Struc:
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536 a.a.
323 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.4.17
- 3',5'-cyclic-nucleotide phosphodiesterase.
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Reaction:
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a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H+
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nucleoside 3',5'-cyclic phosphate
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+
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H2O
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=
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nucleoside 5'-phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
