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PDBsum entry 4nnd
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PDB id:
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Hydrolase
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Title:
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Structural basis of ptpn18 fingerprint on distinct her2 tyrosine phosphorylation sites
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Structure:
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Tyrosine-protein phosphatase non-receptor type 18. Chain: a, b, d, g. Fragment: tyrosine-protein phosphatase domain (unp residues 6-295). Synonym: brain-derived phosphatase. Engineered: yes. Mutation: yes. Receptor tyrosine-protein kinase erbb-2. Chain: f, c, e, h. Fragment: phosphorylated peptide (unp residues 1109-1114).
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn18, bdp1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.50Å
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R-factor:
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0.264
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R-free:
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0.291
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Authors:
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H.Wang,F.Yang,D.Yang,Y.Du
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Key ref:
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H.Wang
et al.
Structural basis of ptpn18 fingerprint on distinct he tyrosine phosphorylation sites.
To be published,
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Date:
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17-Nov-13
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Release date:
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19-Nov-14
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PROCHECK
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Headers
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References
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Q99952
(PTN18_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 18 from Homo sapiens
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Seq:
Struc:
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460 a.a.
283 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
