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UniProt functional annotation for P16872 | ||
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| UniProt code: P16872. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
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| Subunit: | |
The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. {ECO:0000269|PubMed:24632570}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Spleen, thymus and fetal liver. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Ptm: | |
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. {ECO:0000250}. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.