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UniProt functional annotation for Q8CII9 | ||
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| UniProt code: Q8CII9. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. {ECO:0000269|PubMed:10974032}. |
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| Subunit: | |
The TSLP receptor is a heterodimer of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex. {ECO:0000269|PubMed:24632570}. |
| Subcellular location: | |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform 3]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform 2]: Secreted. |
| Tissue specificity: | |
High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells. |
| Induction: | |
Up-regulated in the myeloid 32D cell line by granulocyte colony-stimulating factor (G-CSF). |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.