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PDBsum entry 4n9f

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protein metals Protein-protein interface(s) links
Ligase/viral protein PDB id
4n9f

 

 

 

 

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Contents
Protein chains
(+ 6 more) 299 a.a.
(+ 6 more) 87 a.a.
(+ 4 more) 95 a.a.
(+ 5 more) 146 a.a.
(+ 6 more) 172 a.a.
90 a.a.
155 a.a.
79 a.a.
Metals
_ZN ×12
PDB id:
4n9f
Name: Ligase/viral protein
Title: Crystal structure of the vif-cbfbeta-cul5-elob-eloc pentameric complex
Structure: Cullin-5. Chain: u, c, i, o, v, f, l, r, x, 3, 9, w. Fragment: unp residues 12-321. Synonym: cul-5, vasopressin-activated calcium-mobilizing receptor 1, vacm-1. Engineered: yes. Transcription elongation factor b polypeptide 1. Chain: y, e, k, q, z, h, n, t, z, 5, t, b. Synonym: elongin 15 kda subunit, elongin-c, eloc, RNA polymerase ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul5, vacm1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: eloc, tceb1. Gene: elob, tceb2. Gene: cbfb, cbfbeta.
Resolution:
3.30Å     R-factor:   0.265     R-free:   0.324
Authors: Y.Y.Guo,L.Y.Dong,Z.W.Huang
Key ref: Y.Y.Guo et al. (2014). Structural basis for hijacking cbf-B and cul5 e3 liga complex by HIV-1 vif. Nature, 505, 229.
Date:
21-Oct-13     Release date:   08-Jan-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q93034  (CUL5_HUMAN) -  Cullin-5 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
780 a.a.
299 a.a.*
Protein chains
Pfam   ArchSchema ?
Q15369  (ELOC_HUMAN) -  Elongin-C from Homo sapiens
Seq:
Struc:
112 a.a.
87 a.a.
Protein chains
Pfam   ArchSchema ?
Q15370  (ELOB_HUMAN) -  Elongin-B from Homo sapiens
Seq:
Struc:
118 a.a.
95 a.a.
Protein chains
Pfam   ArchSchema ?
Q13951  (PEBB_HUMAN) -  Core-binding factor subunit beta from Homo sapiens
Seq:
Struc:
182 a.a.
146 a.a.
Protein chains
Pfam   ArchSchema ?
P12504  (VIF_HV1N5) -  Virion infectivity factor from Human immunodeficiency virus type 1 group M subtype B (isolate NY5)
Seq:
Struc:
192 a.a.
172 a.a.
Protein chain
Pfam   ArchSchema ?
Q15370  (ELOB_HUMAN) -  Elongin-B from Homo sapiens
Seq:
Struc:
118 a.a.
90 a.a.
Protein chain
Pfam   ArchSchema ?
Q13951  (PEBB_HUMAN) -  Core-binding factor subunit beta from Homo sapiens
Seq:
Struc:
182 a.a.
155 a.a.
Protein chain
Pfam   ArchSchema ?
Q15370  (ELOB_HUMAN) -  Elongin-B from Homo sapiens
Seq:
Struc:
118 a.a.
79 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

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