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UniProt functional annotation for P00669 | ||
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| UniProt code: P00669. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
This enzyme hydrolyzes both single- and double-stranded RNA. |
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| Catalytic activity: | |
Reaction=An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; Evidence={ECO:0000269|PubMed:4664228}; |
| Catalytic activity: | |
Reaction=An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; Evidence={ECO:0000269|PubMed:4664228}; |
| Activity regulation: | |
Allosteric regulation by both substrate and reaction products. |
| Subunit: | |
Homodimer; disulfide-linked. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Seminal plasma. Can reach 3% of the protein content of this fluid. |
| Miscellaneous: | |
Progressive deamidation of Asn-93 transforms the homodimer (beta- 2) into and heterodimer (alpha-beta) and finally a doubly deamidated dimer (alpha-2). {ECO:0000269|PubMed:2057997}. |
| Similarity: | |
Belongs to the pancreatic ribonuclease family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.