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UniProt functional annotation for Q830Y8 | ||
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| UniProt code: Q830Y8. |
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| Organism: | |
Enterococcus faecalis (strain ATCC 700802 / V583). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus. |
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| Function: | |
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. {ECO:0000256|RuleBase:RU365100}. |
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| Catalytic activity: | |
Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017, ChEBI:CHEBI:456216; EC=6.3.4.21; Evidence={ECO:0000256|ARBA:ARBA00001240, ECO:0000256|RuleBase:RU365100}; |
| Pathway: | |
Cofactor biosynthesis; NAD(+) biosynthesis. {ECO:0000256|ARBA:ARBA00004790}. |
| Pathway: | |
Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1. {ECO:0000256|ARBA:ARBA00004952, ECO:0000256|RuleBase:RU365100}. |
| Ptm: | |
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. {ECO:0000256|RuleBase:RU365100}. |
| Similarity: | |
Belongs to the NAPRTase family. {ECO:0000256|ARBA:ARBA00010897, ECO:0000256|RuleBase:RU365100}. |
Annotations taken from UniProtKB at the EBI.