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PDBsum entry 4myq
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protein ligands metals links
Hydrolase/hydrolase inhibitor PDB id
4myq

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
345 a.a.
Ligands
19T
EDO ×3
Metals
_MG
_ZN
_NA
Waters ×375
PDB id:
4myq
Name: Hydrolase/hydrolase inhibitor
Title: Selective inhibition of the catalytic domain of human phosphodiesterase 4b with a-33
Structure: Camp-specific 3',5'-cyclic phosphodiesterase 4b. Chain: a. Fragment: unp residues 324-691. Synonym: dpde4, pde32. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4, pde4b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
1.90Å     R-factor:   0.190     R-free:   0.222
Authors: D.Fox Iii,T.E.Edwards
Key ref: D.Fox et al. (2014). Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cell Signal, 26, 657-663. PubMed id: 24361374 DOI: 10.1016/j.cellsig.2013.12.003
Date:
27-Sep-13     Release date:   01-Jan-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q07343  (PDE4B_HUMAN) -  cAMP-specific 3',5'-cyclic phosphodiesterase 4B from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		736 a.a.
345 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.4.53  - 3',5'-cyclic-AMP phosphodiesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 3',5'-cyclic AMP + H2O = AMP + H+
3',5'-cyclic AMP
 + H2O
 = AMP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.1016/j.cellsig.2013.12.003 Cell Signal 26:657-663 (2014)
PubMed id: 24361374  
 
 
Structural basis for the design of selective phosphodiesterase 4B inhibitors.
D.Fox, A.B.Burgin, M.E.Gurney.
 
  ABSTRACT  
 
No abstract given.

 

 

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