PDBsum entry 4mvf

Transferase/transferase inhibitor

PDB id: 4mvf

Contents

Protein chain

408 a.a.

Ligands

STU

GOL

Metals

_CA ×3

Waters ×226

PDB id:

4mvf

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of plasmodium falciparum cdpk2 complexed with inhibitor staurosporine

Structure:

Calcium-dependent protein kinase 2. Chain: a. Synonym: pfcdpk2. Engineered: yes

Source:

Plasmodium falciparum k1. Organism_taxid: 5839. Strain: k1. Gene: cdpk2, cpk2, pff0520w. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.00Å R-factor: 0.195 R-free: 0.230

Authors:

L.Lauciello,L.Pernot,L.Scapozza,R.Perozzo

Key ref:

L.Lauciello et al. P. Falciparum calcium-Dependent protein kinase 2 (pfc first crystal structure and virtual ligand screening. To be published, .

Date:

24-Sep-13 Release date: 03-Sep-14

Protein chain

O15865  (CDPK2_PLAFK) -  Calcium-dependent protein kinase 2 from Plasmodium falciparum (isolate K1 / Thailand)

Seq: 513 a.a.

Struc: 408 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site