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UniProt functional annotation for Q9I5Q5 | ||
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| UniProt code: Q9I5Q5. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa (PubMed:24819062). {ECO:0000255|HAMAP-Rule:MF_01270, ECO:0000269|PubMed:24819062}. |
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| Catalytic activity: | |
Reaction=1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate; Xref=Rhea:RHEA:24952, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58690, ChEBI:CHEBI:58722, ChEBI:CHEBI:456216; EC=2.7.1.170; Evidence={ECO:0000255|HAMAP-Rule:MF_01270}; |
| Pathway: | |
Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. {ECO:0000255|HAMAP-Rule:MF_01270, ECO:0000269|PubMed:24819062}. |
| Pathway: | |
Cell wall biogenesis; peptidoglycan recycling. {ECO:0000255|HAMAP-Rule:MF_01270, ECO:0000269|PubMed:24819062}. |
| Disruption phenotype: | |
Cells lacking this gene accumulate anhMurNAc. Deletion of this gene increases fosfomycin sensitivity. Growth rate is not affected. {ECO:0000269|PubMed:24819062}. |
| Similarity: | |
Belongs to the anhydro-N-acetylmuramic acid kinase family. {ECO:0000255|HAMAP-Rule:MF_01270}. |
Annotations taken from UniProtKB at the EBI.