PDBsum entry 4mgz

Signaling protein/gtp-binding protein

PDB id: 4mgz

Contents

Protein chains

632 a.a.

150 a.a.

Ligands

HR6 ×2

SO4

Waters ×67

PDB id:

4mgz

Name:

Signaling protein/gtp-binding protein

Title:

Selective activation of epac1 and epac2

Structure:

Rap guanine nucleotide exchange factor 4. Chain: e. Fragment: unp residues 324-1011. Synonym: exchange factor directly activated by camp 2, exchange protein directly activated by camp 2, epac 2, camp-dependent rap1 guanine-nucleotide exchange factor, camp-regulated guanine nucleotide exchange factor ii, camp-gefii. Engineered: yes. Ras-related protein rap-1b.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: rapgef4, cgef2, epac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

3.00Å R-factor: 0.240 R-free: 0.264

Authors:

H.Rehmann

Key ref:

H.Rehmann Selective activation of epac1 and epac2. To be published, .

Date:

29-Aug-13 Release date: 03-Sep-14

Protein chain

Q9EQZ6  (RPGF4_MOUSE) -  Rap guanine nucleotide exchange factor 4 from Mus musculus

Seq: 1011 a.a.

Struc: 632 a.a.

Protein chain

P61224  (RAP1B_HUMAN) -  Ras-related protein Rap-1b from Homo sapiens

Seq: 184 a.a.

Struc: 150 a.a.

Enzyme reactions

• Enzyme class: Chain R: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

GTP + H2O = GDP (Bound ligand (Het Group name = HR6) matches with 52.63% similarity) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site