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UniProt functional annotation for Q9EQZ6 | ||
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| UniProt code: Q9EQZ6. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. {ECO:0000269|PubMed:11056535}. |
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| Subunit: | |
Interacts with RAP1B, RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. {ECO:0000269|PubMed:11056535, ECO:0000269|PubMed:18660803}. |
| Subcellular location: | |
Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue specificity: | |
Expressed in cerebellum, pituitary, adrenal gland and liver. {ECO:0000269|PubMed:11056535}. |
| Domain: | |
The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2. {ECO:0000250}. |
| Domain: | |
The DEP domain is involved in membrane localization independent from regulation by cAMP. {ECO:0000250}. |
| Miscellaneous: | |
[Isoform 1]: Produced by alternative promoter usage. |
| Miscellaneous: | |
[Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.