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PDBsum entry 4m6a
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De novo protein
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PDB id
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4m6a
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Contents |
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87 a.a.
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(+ 2 more)
91 a.a.
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References listed in PDB file
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Key reference
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Title
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N-Terminal β-Strand swapping in a consensus-Derived alternative scaffold driven by stabilizing hydrophobic interactions.
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Authors
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J.Luo,
A.Teplyakov,
G.Obmolova,
T.J.Malia,
W.Chan,
S.A.Jacobs,
K.T.O'Neil,
G.L.Gilliland.
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Ref.
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Proteins, 2014,
82,
1527-1533.
[DOI no: ]
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PubMed id
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Abstract
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The crystal structure of an N-terminal β-strand-swapped consensus-derived
tenascin FN3 alternative scaffold has been determined. A comparison with the
unswapped structure reveals that the side chain of residue F88 orients
differently and packs more tightly with the hydrophobic core of the domain.
Dimer formation also results in the burial of a hydrophobic patch on the surface
of the domain. Thus, it appears that tighter packing of F88 in the hydrophobic
core and burial of surface hydrophobicity provide the driving forces for the
N-terminal β-strand swapping, leading to the formation of a stable compact
dimer. Proteins 2014; 82:1527-1533. © 2014 Wiley Periodicals, Inc.
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