UniProt functional annotation for Q9H6Q3



	UniProt functional annotation for Q9H6Q3

UniProt code: Q9H6Q3.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}.

Subunit: Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated). {ECO:0000250, ECO:0000269|PubMed:11696592}.

Subcellular location: Cytoplasm.

Subcellular location: [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.

Subcellular location: [Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.

Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.

Domain: The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.

Ptm: Phosphorylated by CSF1R. {ECO:0000250}.

Miscellaneous: [Isoform 3]: Produced by alternative initiation at Met- 28 of isoform 1. {ECO:0000305}.

Miscellaneous: [Isoform 4]: Produced by alternative initiation at Met- 28 of isoform 2. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269\|PubMed:11696592}.


Subunit:		Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated). {ECO:0000250, ECO:0000269\|PubMed:11696592}.
Subcellular location:		Cytoplasm.
Subcellular location:		[Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Subcellular location:		[Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.
Tissue specificity:		Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.
Domain:		The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.
Ptm:		Phosphorylated by CSF1R. {ECO:0000250}.
Miscellaneous:		[Isoform 3]: Produced by alternative initiation at Met- 28 of isoform 1. {ECO:0000305}.
Miscellaneous:		[Isoform 4]: Produced by alternative initiation at Met- 28 of isoform 2. {ECO:0000305}.