 |
PDBsum entry 4m11
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oxidoreductase/oxidoreductase inhibitor
|
PDB id
|
|
|
|
4m11
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Oxidoreductase/oxidoreductase inhibitor
|
|
|
Title:
|
|
Crystal structure of murine cyclooxygenase-2 complex with meloxicam
|
|
Structure:
|
|
Prostaglandin g/h synthase 2. Chain: a, b, c, d. Fragment: unp residues 18-569. Synonym: cyclooxygenase-2, cox-2, glucocorticoid-regulated inflammatory cyclooxygenase, gripghs, macrophage activation- associated marker protein p71/73, pes-2, phs ii, prostaglandin h2 synthase 2, pgh synthase 2, pghs-2, prostaglandin-endoperoxide synthase 2, tis10 protein. Engineered: yes
|
|
Source:
|
|
Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptgs2, cox-2, cox2, pghs-b, tis10. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
Resolution:
|
|
|
2.45Å
|
R-factor:
|
0.203
|
R-free:
|
0.231
|
|
|
Authors:
|
|
S.Xu,S.Banerjee,D.J.Hermanson,L.J.Marnett
|
|
Key ref:
|
|
S.Xu
et al.
(2014).
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
J Biol Chem,
289,
6799-6808.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
02-Aug-13
|
Release date:
|
22-Jan-14
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q05769
(PGH2_MOUSE) -
Prostaglandin G/H synthase 2 from Mus musculus
|
|
|
|
Seq:
Struc:
|
|
|
|
604 a.a.
552 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.1.14.99.1
- prostaglandin-endoperoxide synthase.
|
|
|
|
|
|
|
Reaction:
|
|
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
|
|
|
|
|
|
(5Z,8Z,11Z,14Z)-eicosatetraenoate
|
+
|
AH2
|
+
|
2
×
O2
|
=
|
prostaglandin H2
|
+
|
|
+
|
H2O
Bound ligand (Het Group name = )
matches with 51.11% similarity
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
DOI no:
|
J Biol Chem
289:6799-6808
(2014)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
|
|
S.Xu,
D.J.Hermanson,
S.Banerjee,
K.Ghebreselasie,
G.M.Clayton,
R.M.Garavito,
L.J.Marnett.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
