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PDBsum entry 4lys
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Protein binding/inhibitor
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PDB id
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4lys
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References listed in PDB file
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Key reference
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Title
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4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
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Authors
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X.Lucas,
D.Wohlwend,
M.Hügle,
K.Schmidtkunz,
S.Gerhardt,
R.Schüle,
M.Jung,
O.Einsle,
S.Günther.
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Ref.
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Angew Chem Int Ed Engl, 2013,
52,
14055-14059.
[DOI no: ]
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PubMed id
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Abstract
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Bromodomains are acetyllysine epigenetic mark reader proteins. Small molecules
inhibiting them have potential as anti-inflammatory, antiviral, and anticancer
agents. A 4-acyl pyrrole derivative (see yellow structure in recognition pocket)
has been identified that potently inhibits specific bromodomains and exhibits
antiproliferative activity against leukemia cell lines.
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