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PDBsum entry 4lxs
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Immune system/cytokine
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PDB id
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4lxs
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References listed in PDB file
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Key reference
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Title
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Structure of the toll-Spatzle complex, A molecular hub in drosophila development and innate immunity.
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Authors
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C.Parthier,
M.Stelter,
C.Ursel,
U.Fandrich,
H.Lilie,
C.Breithaupt,
M.T.Stubbs.
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Ref.
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Proc Natl Acad Sci U S A, 2014,
111,
6281-6286.
[DOI no: ]
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PubMed id
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Abstract
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Drosophila Toll receptors are involved in embryonic development and the immune
response of adult flies. In both processes, the only known Toll receptor ligand
is the human nerve growth factor-like cystine knot protein Spätzle. Here we
present the crystal structure of a 1:1 (nonsignaling) complex of the full-length
Toll receptor ectodomain (ECD) with the Spätzle cystine knot domain dimer. The
ECD is divided into two leucine-rich repeat (LRR) domains, each of which is
capped by cysteine-rich domains. Spätzle binds to the concave surface of the
membrane-distal LRR domain, in contrast to the flanking ligand interactions
observed for mammalian Toll-like receptors, with asymmetric contributions from
each Spätzle protomer. The structure allows rationalization of existing genetic
and biochemical data and provides a framework for targeting the immune systems
of insects of economic importance, as well as a variety of invertebrate disease
vectors.
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