PDBsum entry 4lsg

Membrane protein, transport protein

PDB id: 4lsg

Contents

Protein chains

1182 a.a.

Metals

_HG ×12

PDB id:

4lsg

Name:

Membrane protein, transport protein

Title:

Structure of mouse p-glycoprotein

Structure:

Multidrug resistance protein 1a. Chain: a, b. Synonym: atp-binding cassette sub-family b member 1a, mdr1a, multidrug resistance protein 3, p-glycoprotein 3. Engineered: yes. Mutation: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: abcb1a, abcb4, mdr1a, mdr3, pgy-3, pgy3. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

3.80Å R-factor: 0.338 R-free: 0.357

Authors:

G.Chang,P.Szewczyk

Date:

22-Jul-13 Release date: 31-Jul-13

Protein chains

P21447  (MDR1A_MOUSE) -  ATP-dependent translocase ABCB1 from Mus musculus

Seq: 1276 a.a.

Struc: 1182 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 1: E.C.7.6.2.1 - P-type phospholipid transporter.
• Reaction: ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2
• Enzyme class 2: E.C.7.6.2.2 - ABC-type xenobiotic transporter.
• Reaction: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site