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UniProt functional annotation for Q4KTA7 | ||
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| UniProt code: Q4KTA7. |
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| Organism: | |
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. |
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| Function: | |
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. {ECO:0000269|PubMed:18039659, ECO:0000269|PubMed:24055314}. |
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| Catalytic activity: | |
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE- ProRule:PRU00405, ECO:0000269|PubMed:18039659, ECO:0000269|PubMed:24055314}; |
| Subunit: | |
Catalytic subunit of the telomerase holoenzyme complex composed minimally of TERT and the telomerase RNA template component (TERC). {ECO:0000269|PubMed:18039659, ECO:0000269|PubMed:24055314}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:O14746}. Chromosome, telomere {ECO:0000250|UniProtKB:O14746}. |
| Tissue specificity: | |
Detected at highest levels in gill, ovary and testis, and at lower levels in brain, eye, heart, skin, spleen and stomach. {ECO:0000269|PubMed:15961261}. |
| Developmental stage: | |
Expressed at higher levels in actively dividing cells. {ECO:0000269|PubMed:15961261}. |
| Similarity: | |
Belongs to the reverse transcriptase family. Telomerase subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.