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UniProt functional annotation for P21372 | ||
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| UniProt code: P21372. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. {ECO:0000269|PubMed:11927574, ECO:0000269|PubMed:14610285, ECO:0000269|PubMed:16314500, ECO:0000269|PubMed:8065365, ECO:0000269|PubMed:8405998, ECO:0000269|PubMed:8622683, ECO:0000269|PubMed:8969184, ECO:0000269|PubMed:8969185}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
| Subunit: | |
Interacts with the U2 snRNP and HSH155. {ECO:0000269|PubMed:11927574, ECO:0000269|PubMed:16314500}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:14562095}. |
| Domain: | |
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. |
| Miscellaneous: | |
Present with 358 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.