UniProt functional annotation for B0BLW3



	UniProt functional annotation for B0BLW3

UniProt code: B0BLW3.

Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.

Function: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids (By similarity). {ECO:0000250|UniProtKB:A2ARI4, ECO:0000269|PubMed:21909076}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9BXB1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXB1}.

Developmental stage: Maternally and zygotically expressed. Zygotic expression increases after gastrula stage. Expressed in all three germ layers. {ECO:0000269|PubMed:21909076}.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.



Function:		Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids (By similarity). {ECO:0000250\|UniProtKB:A2ARI4, ECO:0000269\|PubMed:21909076}.


Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q9BXB1}; Multi-pass membrane protein {ECO:0000250\|UniProtKB:Q9BXB1}.
Developmental stage:		Maternally and zygotically expressed. Zygotic expression increases after gastrula stage. Expressed in all three germ layers. {ECO:0000269\|PubMed:21909076}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.