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PDBsum entry 4li2
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Hormone receptor/signaling protein
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PDB id
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4li2
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References listed in PDB file
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Key reference
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Title
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Crystal structures of lgr4 and its complex with r-Spondin1.
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Authors
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K.Xu,
Y.Xu,
K.R.Rajashankar,
D.Robev,
D.B.Nikolov.
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Ref.
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Structure, 2013,
21,
1683-1689.
[DOI no: ]
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PubMed id
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Abstract
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The leucine-rich repeat-containing G-protein-coupled receptors (Lgrs) are a
large membrane protein family mediating signaling events during development and
in the adult organism. Type 2 Lgrs, including Lgr4, Lgr5, and Lgr6, play crucial
roles in embryonic development and in several cancers. They also regulate adult
stem cell maintenance via direct association with proteins in the Wnt signaling
pathways, including Lrp5/6 and frizzled receptors. The R-spondins (Rspo) were
recently identified as functional ligands for type 2 Lgrs and were shown to
synergize with both canonical and noncanonical Wnt signaling pathways. We
determined and report the structure of the Lgr4 ectodomain alone and bound to
Rspo1. The structures reveal an extended horseshoe leucine-rich repeat (LRR)
receptor architecture that binds, with its concave side, the ligand furin-like
repeats via an intimate interface. The molecular details of
ligand/receptor recognition provide insight into receptor activation and could
serve as template for stem-cell-based regenerative therapeutics development.
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