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UniProt functional annotation for P74416 | ||
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| UniProt code: P74416. |
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| Organism: | |
Synechocystis sp. (strain PCC 6803 / Kazusa). |
| Taxonomy: | |
Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis; unclassified Synechocystis. |
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| Function: | |
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. {ECO:0000255|HAMAP-Rule:MF_00711}. |
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| Catalytic activity: | |
Reaction=glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl- [glycine-cleavage complex H protein] + CO2; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2; Evidence={ECO:0000255|HAMAP- Rule:MF_00711}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000255|HAMAP-Rule:MF_00711}; |
| Subunit: | |
The glycine cleavage system is composed of four proteins: P, T, L and H. {ECO:0000255|HAMAP-Rule:MF_00711}. |
| Similarity: | |
Belongs to the GcvP family. {ECO:0000255|HAMAP- Rule:MF_00711}. |
Annotations taken from UniProtKB at the EBI.