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PDBsum entry 4lg8
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DNA binding protein
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PDB id
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4lg8
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the wd40 domain of human prpf19.
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Authors
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Y.Zhang,
Y.Li,
X.Liang,
Z.Zhu,
H.Sun,
H.He,
J.Min,
S.Liao,
Y.Liu.
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Ref.
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Biochem Biophys Res Commun, 2017,
493,
1250-1253.
[DOI no: ]
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PubMed id
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Abstract
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Human Pre-mRNA Processing factor 19 (hPRPF19) is an important component in human
spliceosome machinery. hPRPF19 contains a WD40 repeats domain at its C-terminus,
which is also conserved in yeast. Here we determined the crystal structure of
the C-terminal WD40 repeat domain of hPRPF19 by X-ray crystallography. Our
structural analysis revealed some significantly different structure features
between the human and yeast Prp19 WD40 repeat domain. However, there are also
conserved clusters of residues at the bottom surface of the fourth and the fifth
WD40 repeats, which provides the important implication for the conserved Prp19
proteins in both human and yeast.
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