PDBsum entry 4kv4

Transcription

PDB id: 4kv4

Contents

Protein chain

111 a.a.

Ligands

THR-PHE-ALY-SER-ILE

DTT

Waters ×57

PDB id:

4kv4

Name:

Transcription

Title:

Brd4 bromodomain 2 in complex with acetylated rel peptide

Structure:

Bromodomain-containing protein 4. Chain: a. Fragment: unp residues 351-459. Synonym: protein hunk1. Engineered: yes. Rel peptide. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.00Å R-factor: 0.210 R-free: 0.258

Authors:

H.Zhang,S.K.Nair

Key ref:

Z.Zou et al. (2014). Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene, 33, 2395-2404. PubMed id: 23686307 DOI: 10.1038/onc.2013.179

Date:

22-May-13 Release date: 26-Jun-13

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 111 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1038/onc.2013.179

Oncogene 33:2395-2404 (2014)

PubMed id: 23686307

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA.

Z.Zou, B.Huang, X.Wu, H.Zhang, J.Qi, J.Bradner, S.Nair, L.F.Chen.

ABSTRACT

No abstract given.