|
|
||
|
|
|
|
|
UniProt functional annotation for Q1RMX3 | ||
|
|
|
|
|
|
||
| UniProt code: Q1RMX3. |
|
||
| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
|
||
|
||
| Function: | |
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). {ECO:0000250}. |
|
||
| Subunit: | |
Interacts with HIF3A (via C-terminus domain). Interacts with BOP. {ECO:0000250|UniProtKB:P70345}. |
| Subcellular location: | |
Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane (By similarity). {ECO:0000250}. |
| Domain: | |
The BH4 motif seems to be involved in the anti-apoptotic function. {ECO:0000250}. |
| Domain: | |
The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 (By similarity). {ECO:0000250}. |
| Similarity: | |
Belongs to the Bcl-2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.