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PDBsum entry 4k1e

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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
4k1e
Jmol PyMol
Contents
Protein chains
223 a.a.
14 a.a.
Ligands
MPD
Metals
_LI
Waters ×115
PDB id:
4k1e
Name: Hydrolase/hydrolase inhibitor
Title: Atomic resolution crystal structures of kallikrein-related p complexed with a modified sfti inhibitor fcqr
Structure: Kallikrein-4. Chain: a. Fragment: related peptidase 4, unp residues 31-253. Synonym: enamel matrix serine proteinase 1, kallikrein-like 1, klk-l1, prostase, serine protease 17. Engineered: yes. Trypsin inhibitor 1. Chain: b. Synonym: sfti-1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: klk4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Helianthus annuus. Common sunflower.
Resolution:
1.30Å     R-factor:   0.141     R-free:   0.170
Authors: O.V.Ilyichova,J.E.Swedberg,S.J.De Veer,K.C.Sit,J.M.Harris,A.
Key ref: B.T.Riley et al. (2016). Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. Sci Rep, 6, 35385. PubMed id: 27767076 DOI: 10.1038/srep35385
Date:
04-Apr-13     Release date:   09-Apr-14    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9Y5K2  (KLK4_HUMAN) -  Kallikrein-4
Seq:
Struc:
254 a.a.
223 a.a.*
Protein chain
Pfam  
Q4GWU5  (SFTI1_HELAN) -  Trypsin inhibitor 1
Seq:
Struc:
56 a.a.
14 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.3.4.21.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     amelogenesis   3 terms 
  Biochemical function     protein binding     6 terms  

 

 
DOI no: 10.1038/srep35385 Sci Rep 6:35385 (2016)
PubMed id: 27767076  
 
 
Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.
B.T.Riley, O.Ilyichova, M.G.Costa, B.T.Porebski, S.J.de Veer, J.E.Swedberg, I.Kass, J.M.Harris, D.E.Hoke, A.M.Buckle.
 
  ABSTRACT  
 
No abstract given.

 

 

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