PDBsum entry 4k11

Transferase

PDB id: 4k11

Contents

Protein chain

448 a.a.

Ligands

0J9

Waters ×272

PDB id:

4k11

Name:

Transferase

Title:

The structure of 1na in complex with src t338g

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a. Fragment: unp residues 87-534. Synonym: c-src tyrosine kinase, proto-oncogenE C-src, pp60c-src, p60- src. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.30Å R-factor: 0.199 R-free: 0.246

Authors:

M.J.Eck,C.H.Yun

Key ref:

M.J.Eck and c.h.yun The structure of 1na in complex with src t338g. To be published, .

Date:

04-Apr-13 Release date: 09-Apr-14

Protein chain

P12931  (SRC_HUMAN) -  Proto-oncogene tyrosine-protein kinase Src from Homo sapiens

Seq: 536 a.a.

Struc: 448 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site