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PDBsum entry 4jxf
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Transferase/transferase inhibitor
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PDB id
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4jxf
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Crystal structure of plk4 kinase with an inhibitor: 400631 ((1r,2s)-2- {3-[(e)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2h-indazol-6-yl}- 5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'h)-one)
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Structure:
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Serine/threonine-protein kinase plk4. Chain: a. Fragment: plk4 kinase. Synonym: polo-like kinase 4, plk-4, serine/threonine-protein kinase 18, serine/threonine-protein kinase sak. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.40Å
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R-factor:
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0.255
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R-free:
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0.268
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Authors:
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W.Qiu,O.Plotnikova,M.Feher,D.E.Awrey,N.Y.Chirgadze
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Key ref:
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W.Qiu
et al.
Crystal structure of plk4 kinase with an inhibitor: 4.
To be published,
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Date:
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28-Mar-13
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Release date:
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02-Apr-14
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PROCHECK
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Headers
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References
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O00444
(PLK4_HUMAN) -
Serine/threonine-protein kinase PLK4 from Homo sapiens
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Seq:
Struc:
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970 a.a.
235 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.21
- polo kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
