|
|
||
|
|
|
|
|
UniProt functional annotation for P13487 | ||
|
|
|
|
|
|
||
| UniProt code: P13487. |
|
||
| Organism: | |
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Leiurus. |
|
||
|
||
| Function: | |
This toxin inhibits numerous potassium channels: shaker (Ki=227 nM), Kv1.2/KCNA2 (nanomolar range), Kv1.3/KCNA3 (nanomolar range), Kv1.5/KCNA5 (Kd>100 nM), Kv1.6/KCNA6 (Ki=22 nM), KCa1.1/KCNMA1 (IC(50)=5.9 nM). It blocks channel activity by a simple bimolecular inhibition process. It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it (PubMed:31276191). It also exhibits pH-specific antimicrobial activities against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans (PubMed:15118082). {ECO:0000269|PubMed:12527813, ECO:0000269|PubMed:15118082, ECO:0000269|PubMed:20007782, ECO:0000269|PubMed:2477548, ECO:0000269|PubMed:31276191, ECO:0000269|PubMed:7517498, ECO:0000269|PubMed:8204618}. |
|
||
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:2453055}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:2453055}. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). {ECO:0000269|PubMed:1696395}. |
| Miscellaneous: | |
This toxin does not or very weakly inhibits Kv1.1/KCNA1, Kv2.1/KCNB1 (Ki>2 uM), Kv3.1/KCNC1 (Kd>1 uM), Kv11.1/KCNH2, KCa2.1/KCNN1 (IC(50)> 1 uM), KCa2.2/ KCNN2 (IC(50)> 1 uM), KCa2.3/ KCNN3 (IC(50)> 1 uM). {ECO:0000269|PubMed:12527813, ECO:0000269|PubMed:12719233, ECO:0000269|PubMed:20007782, ECO:0000269|PubMed:7517498, ECO:0000269|PubMed:8204618}. |
| Similarity: | |
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 01 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.