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PDBsum entry 4jmk

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
4jmk
Jmol PyMol
Contents
Protein chains
151 a.a.
Ligands
SO4 ×4
Waters ×157
PDB id:
4jmk
Name: Hydrolase
Title: Structure of dusp8
Structure: Dual specificity protein phosphatase 8. Chain: a, b. Fragment: unp residues 160-310. Synonym: dual specificity protein phosphatase hvh-5. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dusp8, c11orf81, vh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.178     R-free:   0.207
Authors: D.G.Jeong,S.J.Kim,S.E.Ryu
Key ref: D.G.Jeong et al. (2014). The family-Wide structure and function of human dual-Specificity protein phosphatases. Acta crystallogr.,Sect.D, 70, 421. DOI: 10.1107/S1399004713029866
Date:
14-Mar-13     Release date:   26-Feb-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q13202  (DUS8_HUMAN) -  Dual specificity protein phosphatase 8
Seq:
Struc:
 
Seq:
Struc:
625 a.a.
151 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class 2: E.C.3.1.3.16  - Protein-serine/threonine phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [a protein]-serine/threonine phosphate + H2O = [a protein]- serine/threonine + phosphate
[a protein]-serine/threonine phosphate
+ H(2)O
= [a protein]- serine/threonine
+ phosphate
   Enzyme class 3: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein dephosphorylation   1 term 
  Biochemical function     protein tyrosine/serine/threonine phosphatase activity     2 terms  

 

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