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UniProt functional annotation for Q6RJQ3 | ||
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| UniProt code: Q6RJQ3. |
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| Organism: | |
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. |
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| Function: | |
Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus downregulates their cell surface expression. {ECO:0000269|PubMed:20410314, ECO:0000269|PubMed:23498957}. |
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| Subunit: | |
Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers. {ECO:0000269|PubMed:15640804, ECO:0000269|PubMed:23498957, ECO:0000269|PubMed:23555243}. |
| Subcellular location: | |
Host endoplasmic reticulum membrane; Single-pass membrane protein. |
| Induction: | |
Early-late protein. |
Annotations taken from UniProtKB at the EBI.